Overview

  • Product name
    Anti-TPH2 (phospho S19) antibody
    See all TPH2 primary antibodies
  • Description
    Rabbit polyclonal to TPH2 (phospho S19)
  • Host species
    Rabbit
  • Specificity
    ab72913 is specific for TPH2 phosphorylated at Ser19.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Cow, Zebrafish
  • Immunogen

    Synthetic phospho-peptide corresponding to amino acid residues surrounding phospho-Ser19 of rat TPH2.

  • Positive control
    • Recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII).

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
  • Storage buffer
    Preservative: None
    Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES, pH 7.5
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab72913 is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab72913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).

Target

  • Tissue specificity
    Brain specific.
  • Pathway
    Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
  • Involvement in disease
    Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
    Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
  • Sequence similarities
    Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    Contains 1 ACT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC138871 antibody
    • ADHD7 antibody
    • FLJ37295 antibody
    • MGC138872 antibody
    • Neuronal tryptophan hydroxylase antibody
    • NTPH antibody
    • TPH 2 antibody
    • Tph2 antibody
    • TPH2_HUMAN antibody
    • Tryptophan 5-hydroxylase 2 antibody
    • Tryptophan 5-monooxygenase 2 antibody
    • Tryptophan hydroxylase 2 antibody
    see all

Images

  • All lanes : Anti-TPH2 (phospho S19) antibody (ab72913) at 1/1000 dilution

    Lane 1 : recombinant TPH2 (control)
    Lane 2 : recombinant TPH2 incubated in the presence of Ca2+/calmodulin dependent kinase II (CaMKII)

    Predicted band size: 56 kDa
    Observed band size: 56 kDa



    This image shows the specific immunolabeling of the ~56k TPH2 protein phosphorylated at Ser19.

References

ab72913 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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