Overview

  • Product name

  • Description

    Rabbit polyclonal to TPN
  • Host species

    Rabbit
  • Specificity

    ab196764 detects endogenous level of total TPN protein.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human TPN (N terminal). The exact sequence is proprietary.
    Database link: O15533

  • Positive control

    • THP-1, Raji, M21 and mouse liver extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab196764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.

Target

  • Function

    Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
  • Tissue specificity

    Neutrophils, mostly in fully differentiated cells.
  • Sequence similarities

    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Domain

    The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminus region.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • NGS 17 antibody
    • NGS-17 antibody
    • NGS17 antibody
    • TAP associated protein antibody
    • TAP binding protein antibody
    • TAP binding protein (tapasin) antibody
    • TAP BP antibody
    • TAP-associated protein antibody
    • TAP-binding protein antibody
    • TAPA antibody
    • Tapasin antibody
    • TAPBP antibody
    • TPN antibody
    • TPSN antibody
    • TPSN_HUMAN antibody
    see all

Images

  • All lanes : Anti-TPN antibody (ab196764) at 1/500 dilution

    Lane 1 : THP1 cell extract
    Lane 2 : Raji cell extract
    Lane 3 : M21 cell extract
    Lane 4 : Mouse liver cell extract

    Predicted band size: 48 kDa

References

This product has been referenced in:

  • Dellgren C  et al. Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu180 and Arg239. J Immunol 197:4807-4816 (2016). Read more (PubMed: 27821669) »
See 1 Publication for this product

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