Key features and details
- Rabbit polyclonal to TPP1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TPP1 antibody
See all TPP1 primary antibodies
DescriptionRabbit polyclonal to TPP1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog
Recombinant fragment, corresponding to a sequence within amino acids 66-294 of Human TPP1 (AAH14863).
- 293T, HepG2, Molt4 and Raji cell lysates. A431, H1299, and HeLa, whole cell lysates.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96690 in the following tested applications.
|WB||1/500 - 1/3000. Predicted molecular weight: 61 kDa.|
FunctionLysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
Tissue specificityDetected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Involvement in diseaseDefects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:204500]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.
Sequence similaritiesBelongs to the peptidase S53 family.
modificationsActivated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.
Cellular localizationLysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
- Cell growth inhibiting gene 1 protein antibody
- Cell growth-inhibiting gene 1 protein antibody
- Ceroid lipofuscinosis neuronal 2 antibody
ab96690 has been referenced in 1 publication.
- Gomez-Giro G et al. Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathol Commun 7:222 (2019). PubMed: 31888773