Overview

  • Product name

  • Description

    Rabbit polyclonal to TRAF1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Fusion protein within Human TRAF1 (internal sequence). The exact sequence is proprietary. Fusion protein corresponding to a region derived from internal residues of human TRAF1. The identity of the protein fusion partner is GST.
    Database link: Q13077

  • Positive control

    • Human lymphoma tissue lysate; Human colon cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/15 - 1/50.
WB 1/200 - 1/1000. Predicted molecular weight: 46 kDa.

Target

  • Function

    Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
  • Sequence similarities

    Contains 1 MATH domain.
  • Domain

    The coiled coil domain mediates homo- and hetero-oligomerization.
    The MATH/TRAF domain binds to receptor cytoplasmic domains.
    Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
  • Post-translational
    modifications

    Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
  • Information by UniProt
  • Database links

  • Alternative names

    • 4732496E14Rik antibody
    • EBI6 antibody
    • EBV induced protein 6 antibody
    • Epstein-Barr virus-induced protein 6 antibody
    • MGC:10353 antibody
    • Tnf receptor associated factor 1 antibody
    • TNF receptor-associated factor 1 antibody
    • TRAF 1 antibody
    • TRAF1 antibody
    • TRAF1_HUMAN antibody
    see all

Images

  • Anti-TRAF1 antibody (ab197684) at 1/350 dilution + Human lymphoma tissue lysate at 40 µg

    Predicted band size: 46 kDa


    Exposure time: 1 second


    10% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling TRAF1 with ab197684 at 1/20.

References

ab197684 has not yet been referenced specifically in any publications.

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