Anti-TRAF5 antibody (ab137763)
Key features and details
- Rabbit polyclonal to TRAF5
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TRAF5 antibody
See all TRAF5 primary antibodies -
Description
Rabbit polyclonal to TRAF5 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Cow, Dog -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 1-186 of Human TRAF5 (IniProt ID: O00463).
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Positive control
- HeLa and Jurkat whole cell lysate (ab7899); HeLa cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab137763 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 64 kDa.
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ICC/IF |
1/100 - 1/1000.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 64 kDa. |
ICC/IF
1/100 - 1/1000. |
Target
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Function
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. -
Tissue specificity
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood. -
Sequence similarities
Belongs to the TNF receptor-associated factor family. A subfamily.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger.
Contains 2 TRAF-type zinc fingers. -
Domain
The MATH/TRAF domain binds to receptor cytoplasmic domains. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 507234 Cow
- Entrez Gene: 480019 Dog
- Entrez Gene: 7188 Human
- Omim: 602356 Human
- SwissProt: O00463 Human
- Unigene: 523930 Human
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Alternative names
- MGC:39780 antibody
- RING finger protein 84 antibody
- RNF 84 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab137763 has been referenced in 4 publications.
- Jiang W et al. LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma. J Gene Med 22:e3134 (2020). PubMed: 31656043
- Liang Z et al. MiR-141-3p inhibits cell proliferation, migration and invasion by targeting TRAF5 in colorectal cancer. Biochem Biophys Res Commun 514:699-705 (2019). PubMed: 31078266
- Cai Y & Li Y Upregulation of miR-29b-3p protects cardiomyocytes from hypoxia-induced apoptosis by targeting TRAF5. Cell Mol Biol Lett 24:27 (2019). PubMed: 31011336
- Wu F et al. Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-?B activation. Int J Mol Med 41:555-563 (2018). PubMed: 29115406