Overview

  • Product name

    TRAM 34, KCa3.1 channel blocker
  • Description

    Potent, selective KCa3.1 channel blocker
  • Biological description

    Potent, selective KCa3.1 channel blocker (IC50 = 18 nM). Atherosclerosis and immunosuppressive agent. Active in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    289905-88-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(2-Chlorophenyl)diphenylmethyl]pyrazole
  • Molecular weight

    344.80
  • Molecular formula

    C22H17ClN2
  • PubChem identifier

    656734
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
  • Source

    Synthetic

  • Research areas

Images

  • lomone Labs TRAM 34 blocks KCa3.1 currents in stably transfected 293T cells.

    Currents were elicited by 150 ms voltage ramp from -120mV to +60mV, applied every 10 sec using whole-cell voltage clamp technique (Vh -80mV). A. Superimposed traces of KCa3.1 currents (plotted against the ramp voltage) measured under control conditions and following 2 minutes perfusion of 50 nM, 250 nM, and 1 µM TRAM 34 (ab141885) as indicated. B. Time course of KCa3.1 current (at 0 mV) amplitude change as a result of the application of raising concentrations of TRAM 34 (perfusion duration indicated by the horizontal bar, concentration as indicated).

References

This product has been referenced in:

  • Toyama K  et al. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 118:3025-37 (2008). Read more (PubMed: 18688283) »
  • Schilling T & Eder C TRAM-34 inhibits nonselective cation channels. Pflugers Arch 454:559-63 (2007). Read more (PubMed: 17318643) »
  • Wulff H  et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A 97:8151-6 (2000). Read more (PubMed: 10884437) »

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