Product nameAnti-Transferrin Receptor antibody [MEM-75] (Alexa Fluor® 700)
See all Transferrin Receptor primary antibodies
DescriptionMouse monoclonal [MEM-75] to Transferrin Receptor (Alexa Fluor® 700)
ConjugationAlexa Fluor® 700
The antibody reacts with an extracellular epitope of Transferrin Receptor, a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. It does not block binding of transferrin to the receptor.
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Transferrin Receptor. NALM-6 human pre-B cell line.
- Flow Cyt: K562 cells.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or email@example.com.
Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferPreservative: 0.0975% Sodium azide
Concentration information loading...
- Anti-Transferrin Receptor antibody [MEM-75] (PE) (ab18242)
- Anti-Transferrin Receptor antibody [MEM-75] (APC/Cy7®) (ab233254)
- Anti-Transferrin Receptor antibody [MEM-75] (FITC) (ab239251)
- Anti-Transferrin Receptor antibody [MEM-75] (PerCP/Cy5.5®) (ab239340)
- Anti-Transferrin Receptor antibody [MEM-75] (Biotin) (ab28116)
- Anti-Transferrin Receptor antibody [MEM-75], prediluted (APC) (ab64672)
- Anti-Transferrin Receptor antibody [MEM-75] (ab9179)
Our Abpromise guarantee covers the use of ab270667 in the following tested applications.
|Flow Cyt||Use 4µl for 106 cells.
The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in suspension.
FunctionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Involvement in diseaseImmunodeficiency 46
Sequence similaritiesBelongs to the peptidase M28 family. M28B subfamily.
Contains 1 PA (protease associated) domain.
modificationsN- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
Cellular localizationSecreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
- CD 71 antibody
- CD71 antibody
- CD71 antigen antibody
ab270667 has not yet been referenced specifically in any publications.