Overview

  • Product name

    Anti-Transglutaminase 5/TGM5 antibody
    See all Transglutaminase 5/TGM5 primary antibodies
  • Description

    Rabbit polyclonal to Transglutaminase 5/TGM5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Transglutaminase 5/TGM5 (C terminal).

  • Positive control

    • Human spleen and liver tissues
  • General notes

     This product was previously labelled as Transglutaminase 5

     

Properties

Applications

Our Abpromise guarantee covers the use of ab133786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 80 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
  • Tissue specificity

    Expressed in foreskin keratinocytes.
  • Involvement in disease

    Defects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
  • Sequence similarities

    Belongs to the transglutaminase superfamily. Transglutaminase family.
  • Cellular localization

    Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • Database links

  • Alternative names

    • Protein glutamine gamma glutamyltransferase 5 antibody
    • Protein-glutamine gamma-glutamyltransferase 5 antibody
    • PSS2 antibody
    • TG(X) antibody
    • TGase 5 antibody
    • TGase X antibody
    • TGase-5 antibody
    • TGase5 antibody
    • TGASEX antibody
    • Tgm5 antibody
    • TGM5_HUMAN antibody
    • TGM6 antibody
    • TGMX antibody
    • TGX antibody
    • Transglutaminase X antibody
    • Transglutaminase-5 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin-embedded Human spleen tissue labelling Transglutaminase 5/TGM5 with ab133786 at 5 µg/ml. Primary antibody labelling was followed by a biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

  • Immunohistochemical analysis of formalin fixed, paraffin-embedded Human liver tissue labelling Transglutaminase 5/TGM5 with ab133786 at 5 µg/ml. Primary antibody labelling was followed by a biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab133786 has not yet been referenced specifically in any publications.

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