Overview

  • Product name

    Tranylcypromine, MAO inhibitor
  • Description

    Non-selective, irreversible MAO inhibitor
  • Biological description

    Non-selective, irreversible MAO inhibitor (IC50 values are 2.3 and 0.95 μM for MAO-A and MAO-B respectively). Shows antiproliferative effects on breast cancer cell lines. Shows antidepressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    13492-01-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,2R)-2-Phenylcyclopropan-1-amine hemisulfate
  • Molecular weight

    182.23
  • Molecular formula

    C9H11N.0.5H2SO4
  • PubChem identifier

    11473982
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]([C@H]1N)C2=CC=CC=C2.C1[C@@H]([C@H]1N)C2=CC=CC=C2.OS(=O)(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Romanczyk TB  et al. The antidepressant tranylcypromine alters cellular proliferation and migration in the adult goldfish brain. Anat Rec (Hoboken) 297:1919-26 (2014). Read more (PubMed: 24816924) »
  • Lee HT  et al. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Rep 30:1587-92 (2013). Read more (PubMed: 23900512) »
  • Lenzen S  et al. Monoamine oxidase in pancreatic islets, exocrine pancreas, and liver from rats. Characterization with clorgyline, deprenyl, pargyline, tranylcypromine, and amezinium. Naunyn Schmiedebergs Arch Pharmacol 324:190-5 (1983). Read more (PubMed: 6419132) »

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