Overview

  • Product name

    Anti-TREM1 antibody [RM0138-3C66] - Low endotoxin, Azide free
    See all TREM1 primary antibodies
  • Description

    Rat monoclonal [RM0138-3C66] to TREM1 - Low endotoxin, Azide free
  • Host species

    Rat
  • Tested applications

    Suitable for: WB, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Mouse recombinant protein of the extracellular domain of TREM1

Properties

  • Form

    Lyophilised:Reconstitute with 200 µl sterile PBS (final concentration 500 µg/ml)
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    The IgG fraction of culture supernatant was purified by Protein A affinity chromatography.
  • Clonality

    Monoclonal
  • Clone number

    RM0138-3C66
  • Isotype

    IgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab217161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 26 kDa.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function

    Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
  • Tissue specificity

    Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD354 antibody
    • OTTMUSP00000018206 antibody
    • TREM 1 antibody
    • TREM-1 antibody
    • TREM1 antibody
    • TREM1_HUMAN antibody
    • Triggering receptor expressed on monocytes 1 antibody
    • Triggering receptor expressed on myeloid cells 1 antibody
    • Triggering receptor TREM 1 antibody
    • Triggering receptor TREM1 antibody
    see all

References

This product has been referenced in:

  • Xu P  et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis 10:555 (2019). Read more (PubMed: 31324751) »
See 1 Publication for this product

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