Overview

  • Product name

    Anti-Treslin antibody - C-terminal
    See all Treslin primary antibodies
  • Description

    Rabbit polyclonal to Treslin - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Treslin (C terminal). The exact sequence is proprietary. Peptide corresponds to 19 amino acids near the carboxy terminus (NP_689472).
    Database link: Q7Z2Z1

  • Positive control

    • Human small intestine tissue and tissue lysate.
  • General notes

    Previously labelled as C15orf42. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab191850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 220 kDa (predicted molecular weight: 211 kDa).
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating to CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
  • Sequence similarities

    Belongs to the treslin family.
  • Cellular localization

    Nucleus. Associates with chromatin.
  • Information by UniProt
  • Database links

  • Alternative names

    • C15orf42 antibody
    • chromosome 15 open reading frame 42 antibody
    • replication-stimulating protein antibody
    • SLD3 antibody
    • SLD3 homolog antibody
    • SLD3, yeast , homolog of antibody
    • TICRR antibody
    • TICRR_HUMAN antibody
    • TopBP1-interacting antibody
    • TopBP1-interacting checkpoint and replication regulator antibody
    • Treslin antibody
    see all

Images

  • Anti-Treslin antibody - C-terminal (ab191850) at 1 µg/ml + Human small intestine tissue lysate at 15 µg

    Developed using the ECL technique.

    Predicted band size: 211 kDa
    Observed band size: 220 kDa
    why is the actual band size different from the predicted?

  • Immunohistochemistry analysis of human small intestine tissue, labeling Treslin using ab191850 at 20 μg/mL.

  • Immunohistochemical analysis of paraffin-embedded Human small intestine tissue, labeling Treslin using ab191850 at 5 μg/mL.

References

ab191850 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191850.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up