Overview

  • Product name

  • Description

    Rabbit polyclonal to TREX1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IP, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human TREX1 aa 1-270.
    Database link: Q9NSU2

  • Positive control

    • IHC-P: Human small intestine tissue. IP: HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab238339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/200 - 1/2000.
IHC-P 1/20 - 1/200.

Target

  • Relevance

    TREX1 is the major 3'->5' DNA exonuclease in human cells. The protein is a non processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A mediated cell death. Mutations in this gene result in Aicardi Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • 3' 5' exonuclease TREX1 antibody
    • 3' repair exonuclease 1 antibody
    • AGS1 antibody
    • AGS5 antibody
    • CRV antibody
    • Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody
    • DKFZp434J0310 antibody
    • DNase III antibody
    • DRN3 antibody
    • HERNS antibody
    • Three prime repair exonuclease 1 antibody
    • TREX1 antibody
    see all

Images

  • Paraffin-embedded human small intestine tissue stained for TREX1 using ab238339 at 1/100 dilution in immunohistochemical analysis.

  • TREX1 was immunoprecipitated from 0.5 mg HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell extract with ab238339 at 1/200 dilution. 

    Lane 1: Control rabbit IgG IP (1 μg) in HeLa whole cell lysate.

    Lane 2: ab238339 IP in HeLa whole cell lysate.

    Lane 3: HeLa whole cell lysate 20 μg (Input).

    For Western blotting, an HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the secondary antibody at 1/50,000 dilution.

     

References

ab238339 has not yet been referenced specifically in any publications.

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