• Product name
  • Description
    Rabbit polyclonal to TREX1
  • Host species
  • Specificity
    This antibody will not cross-react with the related protein TREX2.
  • Tested applications
    Suitable for: ICC/IF, WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    A 15 amino acid synthetic peptide from the internal sequence of Human TREX1.

  • Positive control
    • Human spleen tissue lysate. Human spleen tissue.
  • General notes
    The mouse cross reactivity is lot specific. Please contact technical team for more information.



Our Abpromise guarantee covers the use of ab83890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 31 kDa (predicted molecular weight: 39 kDa).
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 2.5 µg/ml.


  • Relevance
    TREX1 is the major 3'->5' DNA exonuclease in human cells. The protein is a non processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A mediated cell death. Mutations in this gene result in Aicardi Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Cellular localization
  • Database links
  • Alternative names
    • 3' 5' exonuclease TREX1 antibody
    • 3' repair exonuclease 1 antibody
    • AGS1 antibody
    • AGS5 antibody
    • CRV antibody
    • Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody
    • DKFZp434J0310 antibody
    • DNase III antibody
    • DRN3 antibody
    • HERNS antibody
    • Three prime repair exonuclease 1 antibody
    • TREX1 antibody
    see all


  • Lane 1 : Anti-TREX1 antibody (ab83890) at 0.5 µg/ml
    Lane 2 : Anti-TREX1 antibody (ab83890) at 1 µg/ml

    All lanes : Human spleen tissue lysate

    Lysates/proteins at 15 µg per lane.

    All lanes : anti-rabbit secondary

    Predicted band size: 39 kDa
    Observed band size: 31 kDa (why is the actual band size different from the predicted?)

  • ab83890 at 2.5µg/ml staining TREX1 in Human spleen tissue.
  • Immunofluorescence of TREX1 in Human Spleen cells using ab83890 at 20 ug/ml.


ab83890 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your reply.

I am a little baffled as to why you are still not getting a signal, but I do not think that it is you, its probably either something really simple that we have overlooked, or its bad luck that we sent you two antibodi...

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Thank you for your reply.

You should be received a vial of ab67192 and a new vial of human spleen lysate tomorrow morning, hopefully this one will work for you. Your new order number is *.

If you have any issues with this new antibody...

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Thank you for getting back to me.

I am really sorry about the issues that you are having. I think the best way forward is for me to send you ab67192 and a new vial of the spleen lysate (it should work as a positive control for ab67192. I would...

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I understand your hesitation to purchase a new antibody and you could try and use 5%BSA as a blocking reagent, but the fact that you are seeing no signal what so ever makes me think that changing the block may not be successful, but it is worth a go. Read More

Thanks for letting me know.

I think the best way to move forward from here is to either replace the current antibody you have with ab67192:


Or, I can refund the cost...

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Thank you for contacting Abcam earlier today.

I am sorry about the issues you have been having with ab83890 in western blot. The antibody is covered under our Abpromise for six months and is guaranteed to work in western blot on human samples....

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Thank you for contacting us.

I have checked with the lab and they sent me the following information:

The antibody was tested in mouse brain and shows a band at the same size as the human spleen image on the datasheet. We have ...

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Thank you for taking the time to contact us. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody.

I would like to reassure you that this antibody is tested and covered by our 6 month guarantee forWB a...

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