Triacsin C, acyl-CoA synthetase inhibitor (ab141888)

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Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
  • Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)

Key features and details

  • Potent, specific acyl-CoA synthetase inhibitor
  • CAS Number: 76896-80-5
  • Purity: > 90%

  • Supplied in DMSO (1 mg/ml)

  • Form / State: Liquid
  • Source: Streptomyces aureofaciens

Overview

  • Product name

    Triacsin C, acyl-CoA synthetase inhibitor

  • Description

    Potent, specific acyl-CoA synthetase inhibitor

  • Biological description

    Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.

  • Purity

    > 90%

  • CAS Number

    76896-80-5

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2E,4E,7E)-2,4,7-Undecatrienalnitrosohydrazone

  • Molecular weight

    207.30

  • Molecular formula

    C11H17N3O

  • PubChem identifier

    9576787

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Supplied in DMSO (1 mg/ml)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCC=CCC=CC=CC=NNN=O

  • Source

    Streptomyces aureofaciens

  • Research areas

Associated products

    Images

    • Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
      Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
      2D chemical structure image of ab141888, Triacsin C, acyl-CoA synthetase inhibitor
    • Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
      Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
      Triacsin C inhibits the proliferation of 3T3-L1 cells.

      Cells were treated with different concentrations of Triacsin C (ab141888) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (2)

    Publishing research using ab141888? Please let us know so that we can cite the reference in this datasheet.

    ab141888 has been referenced in 2 publications.

    • Wong A  et al. Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discov 4:109 (2018). PubMed: 30510774
    • Pinkosky SL  et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun 7:13457 (2016). PubMed: 27892461

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