Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
Key features and details
- Potent, specific acyl-CoA synthetase inhibitor
- CAS Number: 76896-80-5
- Purity: > 90%
Supplied in DMSO (1 mg/ml)
- Form / State: Liquid
- Source: Streptomyces aureofaciens
Overview
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Product name
Triacsin C, acyl-CoA synthetase inhibitor -
Description
Potent, specific acyl-CoA synthetase inhibitor -
Biological description
Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.
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Purity
> 90% -
CAS Number
76896-80-5 -
Chemical structure
Properties
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Chemical name
(2E,4E,7E)-2,4,7-Undecatrienalnitrosohydrazone
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Molecular weight
207.30 -
Molecular formula
C11H17N3O -
PubChem identifier
9576787 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Supplied in DMSO (1 mg/ml)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCC=CCC=CC=CC=NNN=O -
Source
Streptomyces aureofaciens
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Research areas
Images
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Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)2D chemical structure image of ab141888, Triacsin C, acyl-CoA synthetase inhibitor
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Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)Triacsin C inhibits the proliferation of 3T3-L1 cells.Cells were treated with different concentrations of Triacsin C (ab141888) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141888 has been referenced in 2 publications.
- Wong A et al. Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discov 4:109 (2018). PubMed: 30510774
- Pinkosky SL et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun 7:13457 (2016). PubMed: 27892461