Triamcinolone acetonide acetate, Glucocorticoid (ab142469)

Overview

  • Product name

    Triamcinolone acetonide acetate, Glucocorticoid
  • Description

    Glucocorticoid
  • Biological description

    Cell-permeable glucocorticoid. Downregulates VEGF mRNA expression in human retinal pigment epithelial cells with low cytotoxicity.
  • Purity

    > 97%
  • CAS Number

    3870-07-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    9-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-acetate
  • Molecular weight

    476.53
  • Molecular formula

    C26H33FO7
  • PubChem identifier

    19746
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CCC5=CC(=O)C=CC54C)F)O)C)OC(O2)(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hong J  et al. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol 34:912-8 (2012). Read more (PubMed: 22551518) »
  • Zhou H  et al. Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells. Int J Nanomedicine 7:4649-60 (2012). Read more (PubMed: 22942646) »
  • Liu W  et al. Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. Int J Pharm 364:135-41 (2008). Read more (PubMed: 18778760) »

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