Overview

  • Product name
    Trifluoperazine dihydrochloride, calmodulin antagonist
  • Description
    Cell-permeable calmodulin antagonist
  • Biological description
    Cell-permeable calmodulin antagonist. Dopamine receptor antagonist. Stimulates ER Ca2+ ATPase activity at low concentrations and inhibits at higher concentrations. Antipsychotic.
  • Purity
    > 99%
  • CAS Number
    440-17-5
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Feldkamp MD  et al. Allosteric effects of the antipsychotic drug trifluoperazine on the energetics of calcium binding by calmodulin. Proteins 78:2265-82 (2010). Read more (PubMed: 20544963) »
  • Khan SZ  et al. The effects of phenothiazines and other calmodulin antagonists on the sarcoplasmic and endoplasmic reticulum Ca(2+) pumps. Biochem Pharmacol 60:1797-806 (2000). Read more (PubMed: 11108794) »
  • Vandonselaar M  et al. Trifluoperazine-induced conformational change in Ca(2+)-calmodulin. Nat Struct Biol 1:795-801 (1994). Read more (PubMed: 7634090) »
  • Seeman P  et al. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261:717-9 (1976). Read more (PubMed: 945467) »

Customer reviews and Q&As

Answer


Thank you for your technical enquiry. After checking our records it
appears that there is an inaccuracy on the datasheet. I would like to
confirm that ab120739 is an antagonist of calmodulin.
I would like to apologize for this inaccuracy and any inconvenience it
may have caused. Thank you for bringing this matter to our attention
and please be assured that we have updated the information for you.
Please do not hesitate to contact us if you need any more advice or information.

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