Trilostane, 3 beta-hydroxysteroid dehydrogenase inhibitor (ab142997)

Overview

  • Product name

    Trilostane, 3 beta-hydroxysteroid dehydrogenase inhibitor
  • Description

    3 β-hydroxysteroid dehydrogenase inhibitor
  • Biological description

    3 β-hydroxysteroid dehydrogenase inhibitor. Enables the biosynthesis of hormonal steroids in vivo. Orally active.
  • CAS Number

    13647-35-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
  • Molecular weight

    329.43
  • Molecular formula

    C20H27NO3
  • PubChem identifier

    656583
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sambroni E  et al. Fsh controls gene expression in fish both independently of and through steroid mediation. PLoS One 8:e76684 (2013). Read more (PubMed: 24194844) »
  • Bishop CV  et al. Effects of steroid ablation and progestin replacement on the transcriptome of the primate corpus luteum during simulated early pregnancy. Mol Hum Reprod : (2013). Read more (PubMed: 24219889) »
  • Coirini H  et al. Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve. J Neurochem 84:119-26 (2003). Read more (PubMed: 12485408) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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