Key features and details
- Mouse polyclonal to TRIM32
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TRIM32 antibody
See all TRIM32 primary antibodies
DescriptionMouse polyclonal to TRIM32
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Full length protein corresponding to Human TRIM32 aa 1-653.
MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEK LLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMC RSCGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFG EKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELA RSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQAD VALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAAS NIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTR KGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDN SLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDR GSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENRQNEHHLEGGF SIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRY STP
Database link: AAH03154.1
- TRIM32 transfected 293T cell lysate
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Constituent: 100% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab172411 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 72 kDa.|
FunctionHas an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
Tissue specificitySpleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
PathwayProtein modification; protein ubiquitination.
Involvement in diseaseLimb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
Bardet-Biedl syndrome 11 (BBS11) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similaritiesBelongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 5 NHL repeats.
Contains 1 RING-type zinc finger.
Cellular localizationCytoplasm. Localized in cytoplasmic bodies, often located around the nucleus.
- Information by UniProt
- 72 kda Tat interacting Protein antibody
- 72 kDa Tat-interacting protein antibody
- BBS11 antibody
ab172411 has not yet been referenced specifically in any publications.