Product nameAnti-TRIM37/MUL antibody
See all TRIM37/MUL primary antibodies
DescriptionRabbit polyclonal to TRIM37/MUL
Tested applicationsSuitable for: IP, WBmore details
Species reactivityReacts with: Human
Synthetic peptide within Human TRIM37/MUL aa 914-964. The exact sequence is proprietary.
Database link: O94972
- WB: HeLa and HEK-293T cell lysate. IP: HeLa cell lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA
Concentration information loading...
Our Abpromise guarantee covers the use of ab264190 in the following tested applications.
|IP||Use a concentration of 2 - 5 µg/ml.|
|WB||1/2000 - 1/10000.|
FunctionE3 ubiquitin-protein ligase.
PathwayProtein modification; protein ubiquitination.
Involvement in diseaseDefects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
Sequence similaritiesBelongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger.
Cellular localizationCytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
- Information by UniProt
- E3 ubiquitin protein ligase TRIM37 antibody
- E3 ubiquitin-protein ligase TRIM37 antibody
- KIAA0898 antibody
TRIM37/MUL was immunoprecipitated from 1 mg HeLa whole cell lysate using ab2641890 at 3 µg/mg lysate. ab264190 was then used for western blotting at 1 µg/ml.
Lane 1: ab264189 IP in HeLa whole cell lysate.
Lane 2: ab264190 IP in HeLa whole cell lysate.
Lane 3: Control IgG.
Detection: Chemiluminescence with an exposure time of 1 second.
All lanes : Anti-TRIM37/MUL antibody (ab264190) at 0.04 µg/ml
Lane 1 : HeLa whole cell lysate at 50 µg
Lane 2 : HeLa whole cell lysate at 15 µg
Lane 3 : HeLa whole cell lysate at 5 µg
Lane 4 : HEK-293T whole cell lysate at 50 µg
Developed using the ECL technique.
Exposure time: 10 seconds
ab264190 has not yet been referenced specifically in any publications.