Overview

  • Product name

  • Description

    Rabbit polyclonal to TRIM37/MUL
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human TRIM37/MUL aa 902-964.

  • Positive control

    • Raji whole cell lysate; HeLa cells
  • General notes

     This product was previously labelled as TRIM37

     

Properties

Applications

Our Abpromise guarantee covers the use of ab95997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function

    E3 ubiquitin-protein ligase.
  • Tissue specificity

    Ubiquitous.
  • Pathway

    Protein modification; protein ubiquitination.
  • Involvement in disease

    Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
  • Sequence similarities

    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications

    Auto-ubiquitinated.
  • Cellular localization

    Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
  • Information by UniProt
  • Database links

  • Alternative names

    • E3 ubiquitin protein ligase TRIM37 antibody
    • E3 ubiquitin-protein ligase TRIM37 antibody
    • KIAA0898 antibody
    • MUL antibody
    • MUL protein antibody
    • Mulibrey nanism gene antibody
    • Mulibrey nanism protein antibody
    • POB 1 antibody
    • POB1 antibody
    • RING B box coiled coil protein antibody
    • TEF 3 antibody
    • TEF3 antibody
    • TRI37_HUMAN antibody
    • TRIM 37 antibody
    • Trim37 antibody
    • Tripartite motif containing 37 antibody
    • Tripartite motif containing 37 protein antibody
    • Tripartite motif containing protein 37 antibody
    • Tripartite motif-containing protein 37 antibody
    see all

Images

  • Anti-TRIM37/MUL antibody (ab95997) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size: 108 kDa



    7.5% SDS PAGE
  • ab95997, at 1/200 dilution, staining TRIM37/MUL in paraformaldehyde-fixed HeLa cells by Immunofluorescence (Top), and merged with the DNA probe (Bottom).

References

This product has been referenced in:

See 1 Publication for this product

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