Trimebutine maleate, gastrointestinal antispasmotic (ab143727)

Overview

  • Product name

    Trimebutine maleate, gastrointestinal antispasmotic
  • Description

    A gastrointestinal antispasmotic. Various pharmacological effects.
  • Biological description

    A gastrointestinal antispasmotic. Various pharmacological effects. Ca2+ and K+ channel modulator. Peripheral μ, κ and δ opioid receptor agonist. Inhibits Ca2+ currents (IC50 values are 7 and 36 μM at holding potentials of -40 and -60 mV respectively). Reduces IKv amplitude (IC50 = 8 μM). Orally active.
  • Purity

    > 96%
  • CAS Number

    34140-59-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tan W  et al. Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels. Arch Pharm Res 34:979-85 (2011). Read more (PubMed: 21725819) »
  • Long Y  et al. Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome. Eur J Pharmacol 636:159-65 (2010). Read more (PubMed: 20371236) »
  • Roman FJ  et al. Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther 289:1391-7 (1999). Read more (PubMed: 10336531) »
  • Nagasaki M  et al. Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells. Br J Pharmacol 110:399-403 (1993). Read more (PubMed: 8220900) »
  • Nagasaki M  et al. Effect of trimebutine on K+ current in rabbit ileal smooth muscle cells. Eur J Pharmacol 235:197-203 (1993). Read more (PubMed: 8389715) »

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