Trimethylapigenin, KV1.5 and KV11.1 (hERG) channel blocker (ab145558)

Overview

  • Product name

    Trimethylapigenin, KV1.5 and KV11.1 (hERG) channel blocker
  • Description

    KV1.5 and KV11.1 (hERG) channel blocker. CFTR channel blocker.
  • Biological description

    KV1.5 and KV11.1 (hERG) channel blocker (IC50 values are 8 and 30 μM for KV1.5 and hERG respectively). CFTR channel blocker. Putative anti-atrial fibrillation agent. Active in vivo.
  • Purity

    > 96%
  • CAS Number

    5631-70-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Liu Y  et al. Effects of the natural flavone trimethylapigenin on cardiac potassium currents. Biochem Pharmacol 84:498-506 (2012). Read more (PubMed: 22583923) »
  • Sawasdee P  et al. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. Phytother Res 23:1792-4 (2009). Read more (PubMed: 19548291) »
  • Fischer H & Illek B Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo. Cell Physiol Biochem 22:685-92 (2008). Read more (PubMed: 19088450) »

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