• Product name
  • Description
    Goat polyclonal to TRIP15
  • Host species
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide: LNSLNQAVVSKLA, corresponding to C terminal amino acids 421-443 of Human TRIP15.

  • Positive control
  • General notes
    GenBank Accession Number – NP_004227. Gene Ontology terms - protein binding; signal transducer activity; signal transduction; transcription from Pol II promoter; cytoplasm; signalosome complex. LocusLink ID - 9318 (human); 12848 (mouse); 261736 (rat).



Our Abpromise guarantee covers the use of ab4537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 5 µg/ml.
WB Use a concentration of 0.03 - 3 µg/ml. Predicted molecular weight: 51 kDa.Can be blocked with Human TRIP15 peptide (ab23046).


  • Function
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • Sequence similarities
    Belongs to the CSN2 family.
    Contains 1 PCI domain.
  • Post-translational
    Phosphorylated by CK2 and PKD kinases.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALIEN antibody
    • Alien Drosophila himolog of antibody
    • Alien homolog antibody
    • COP 9 antibody
    • COP9 antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 antibody
    • COP9 signalosome complex subunit 2 antibody
    • COPS 2 antibody
    • Cops2 antibody
    • CSN2 antibody
    • CSN2_HUMAN antibody
    • JAB1 containing signalosome subunit 2 antibody
    • JAB1-containing signalosome subunit 2 antibody
    • SGN 2 antibody
    • SGN2 antibody
    • Signalosome subunit 2 antibody
    • Thyroid Hormone Receptor Interactor15 antibody
    • Thyroid Hormone Receptor Interactor 15 antibody
    • Thyroid receptor-interacting protein 15 antibody
    • TR-interacting protein 15 antibody
    • TRIP 15 antibody
    • TRIP-15 antibody
    • TRIP15 antibody
    see all


  • Anti-TRIP15 antibody (ab4537) at 0.03 µg/ml + NIH-3T3 cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 51 kDa

    Primary antibody was incubated for 1 hour.

  • ab4537 (3-5 µg/ml) staining TRIP15 in paraffin-embedded sections of Human thyroid Gland.


This product has been referenced in:
  • Lockwood WW  et al. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS One 8:e63610 (2013). WB . Read more (PubMed: 23658844) »
See 1 Publication for this product

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