Overview

  • Product name

    Tripolin B, Aurora A and B inhibitor
  • Description

    ATP-competitive Aurora A and B inhibitor
  • Biological description

    ATP-competitive Aurora A and B inhibitor (IC50 values are 2.5 and 6 μM for Aurora A and B respectively). Tripolin A (ab144377) analog. Inhibits KDR, IGF1R, EGFR and FGFR (IC50 values are 6.5, 13, 72 and 38 μM respectively).
  • Purity

    > 98%
  • CAS Number

    372164-71-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3Z)-3-(1H-Imidazol-5-ylmethylidene)-1H-indol-2-one
  • Molecular weight

    211.22
  • Molecular formula

    C12H9N3O
  • PubChem identifier

    5714572
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)/C(=C/C3=CN=CN3)/C(=O)N2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kesisova IA  et al. Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules. PLoS One 8:e58485 (2013). Read more (PubMed: 23516487) »
  • Carmena M  et al. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol 21:796-805 (2009). Read more (PubMed: 19836940) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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