Recombinant
RabMAb

Recombinant Anti-TRK fused gene antibody [EPR8766] (Alexa Fluor® 555) (ab211610)

Overview

  • Product name

    Anti-TRK fused gene antibody [EPR8766] (Alexa Fluor® 555)
    See all TRK fused gene primary antibodies
  • Description

    Rabbit monoclonal [EPR8766] to TRK fused gene (Alexa Fluor® 555)
  • Host species

    Rabbit
  • Conjugation

    Alexa Fluor® 555. Ex: 555nm, Em: 565nm
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human TRK fused gene aa 350 to the C-terminus. The exact sequence is proprietary.
    Database link: Q92734

  • Positive control

    • ICC/IF: MCF7 cells
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab211610 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100.

This product gave a positive signal in MCF7 cells fixed with 100% methanol (5 min)

Target

  • Tissue specificity

    Ubiquitous.
  • Involvement in disease

    Defects in TFG are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ36137 antibody
    • HMSNP antibody
    • OTTHUMP00000214045 antibody
    • OTTHUMP00000214046 antibody
    • OTTHUMP00000214047 antibody
    • OTTHUMP00000214048 antibody
    • Protein TFG antibody
    • SPG57 antibody
    • TF6 antibody
    • TFG antibody
    • TFG_HUMAN antibody
    • TRK fused antibody
    • TRK fused gene antibody
    • TRK fused gene protein antibody
    • TRK-fused gene protein antibody
    • TRKT3 antibody
    • TRKT3 oncogene antibody
    see all

Images

  • ab211610 staining TRK fused gene in MCF7 cells. The cells were fixed with 100% methanol and incubated with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block unspecific protein-protein interactions. The cells were then incubated overnight at +4°C with ab211610 at 1/100 dilution (pseudocolored in green) and ab195884, Rat monoclonal [YOL1/34] to Tubulin - Microtubule Marker (Alexa Fluor® 647), at 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).

    Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

References

ab211610 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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