Anti-TrkB (phospho Y706 + Y707) antibody (ab111545)


  • Product name
    Anti-TrkB (phospho Y706 + Y707) antibody
    See all TrkB primary antibodies
  • Description
    Rabbit polyclonal to TrkB (phospho Y706 + Y707)
  • Host species
  • Specificity
    ab111545 detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707 (Human: Tyr706+Tyr707; Mouse: Tyr705+Tyr706; Rat: Tyr705+Tyr706).
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human TrkB around the phosphorylation site of Tyrosine 706 and Tyrosine 707.

  • Positive control
    • Human brain tissue.



Our Abpromise guarantee covers the use of ab111545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function
    Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
  • Tissue specificity
    Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 1 protein kinase domain.
  • Post-translational
    Ligand-mediated auto-phosphorylation.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • AI848316 antibody
    • BDNF tropomyosine receptor kinase B antibody
    • BDNF/NT 3 growth factors receptor antibody
    • BDNF/NT-3 growth factors receptor antibody
    • Brain derived neurotrophic factor receptor antibody
    • C030027L06Rik antibody
    • EC antibody
    • GP145 TrkB antibody
    • GP145-TrkB antibody
    • GP145-TrkB/GP95-TrkB antibody
    • GP95 TrkB antibody
    • Neurotrophic receptor tyrosine kinase 2 antibody
    • Neurotrophic tyrosine kinase receptor type 2 antibody
    • Neurotrophin receptor tyrosine kinase type 2 antibody
    • NTRK 2 antibody
    • Ntrk2 antibody
    • NTRK2_HUMAN antibody
    • Obesity, hyperphagia, and developmental delay, included antibody
    • RATTRKB1 antibody
    • Tkrb antibody
    • Trk B antibody
    • Trk-B antibody
    • TRKB antibody
    • TrkB tyrosine kinase antibody
    • TRKB1 antibody
    • Tropomyosin related kinase B antibody
    • tyrosine kinase receptor B antibody
    • Tyrosine receptor kinase B antibody
    see all


  • ab111545, at 1/50 dilution, staining TrkB in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.


This product has been referenced in:
  • Hassan A  et al. Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression. PLoS One 13:e0197486 (2018). Read more (PubMed: 29775479) »

See 1 Publication for this product

Customer reviews and Q&As

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Mouse Tissue sections (Mammary gland)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: 10mM Sodium citrate pH6
Yes - 0.3% TritonX100 in 1X PBS
Mammary gland
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 24°C

Abcam user community

Verified customer

Submitted Apr 14 2017

Merci d'avoir répondu au questionnaire qui vous a été envoyé. Je suis désolé que les anticorps que vous avez testés ne puissent pas discriminer la TrkA et laTrkC. Comme le montrent les alignements de s&e...

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Le laboratoire où est produit l'anticorps ab111545 m'a informé qu'aucun test n'avait été effectué avec TrkA ou TrkC mais que la détection est très probable due à l'homologie de séquence autour des tyrosines 706 et 707. J'espère que ces informations ...

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Merci de nous avoir contactés. Comme convenu j'ai mis en place l'envoi d'une unité gratuite de ab111545 (, le numéro de la commande est : ******. Concernant le possible croisement de l'anticorps ab111545 avec les protéines ...

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