Overview

  • Product name

  • Description

    Rabbit polyclonal to TrkC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human TrkC (internal sequence). The exact sequence is proprietary.
    Database link: Q16288

  • Positive control

    • ICC/IF: SK-N-SH cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab227164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
  • Tissue specificity

    Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Ligand-mediated auto-phosphorylation.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 2.7.10.1 antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody
    • ETV6 NTRK3 fusion antibody
    • GP145 TrkC antibody
    • gp145(trkC) antibody
    • GP145-TrkC antibody
    • GP145TrkC antibody
    • Neurotrophic tyrosine kinase receptor type 3 antibody
    • Neurotrophin 3 receptor antibody
    • NT 3 growth factor receptor antibody
    • NT 3 growth factor receptor precursor antibody
    • NT 3 receptor antibody
    • NT-3 growth factor receptor antibody
    • Ntrk3 antibody
    • NTRK3_HUMAN antibody
    • OTTHUMP00000192915 antibody
    • TRK C antibody
    • Trk-C antibody
    • TRKC antibody
    • TrkC tyrosine kinase antibody
    • Tyrosine kinase receptor C antibody
    see all

Images

  • Ice-cold methanol-fixed SK-N-SH (human neuroblastoma cell line) cells stained for TrkC (green) using ab227164 at 1/500 dilution in ICC/IF. Nuclear counterstain: Hoechst 33342 (blue).

References

ab227164 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227164.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up