Overview

  • Product name

  • Description

    Rabbit polyclonal to TrkC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Pig, Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human TrkC (internal sequence). The exact sequence is proprietary.
    Database link: Q16288

  • Positive control

    • WB: MOLT-4 and NIH/3T3 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab227289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 94 kDa.

Target

  • Function

    Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
  • Tissue specificity

    Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Ligand-mediated auto-phosphorylation.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 2.7.10.1 antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody
    • ETV6 NTRK3 fusion antibody
    • GP145 TrkC antibody
    • gp145(trkC) antibody
    • GP145-TrkC antibody
    • GP145TrkC antibody
    • Neurotrophic tyrosine kinase receptor type 3 antibody
    • Neurotrophin 3 receptor antibody
    • NT 3 growth factor receptor antibody
    • NT 3 growth factor receptor precursor antibody
    • NT 3 receptor antibody
    • NT-3 growth factor receptor antibody
    • Ntrk3 antibody
    • NTRK3_HUMAN antibody
    • OTTHUMP00000192915 antibody
    • TRK C antibody
    • Trk-C antibody
    • TRKC antibody
    • TrkC tyrosine kinase antibody
    • Tyrosine kinase receptor C antibody
    see all

Images

  • Anti-TrkC antibody (ab227289) at 1/1000 dilution + MOLT-4 (human lymphoblastic leukemia cell line) whole cell lysate at 30 µg

    Predicted band size: 94 kDa



    7.5% SDS-PAGE gel.

  • Anti-TrkC antibody (ab227289) at 1/1000 dilution + NIH/3T3 (mouse embryonic fibroblast cell line) whole cell lysate at 30 µg

    Predicted band size: 94 kDa



    7.5% SDS-PAGE gel.

References

ab227289 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227289.
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