Overview

  • Product name

    Troleandomycin, Cytochrome P450 3A4 inhibitor.
  • Description

    Macrolide antibiotic. Cytochrome P450 3A4 inhibitor.
  • Alternative names

    • Cyclamycin
    • Evramicina
    • Oleandocetine
    • Oleandomycin 2'',4',11-Triacetate
    • Oleandomycin Triacetate
    • Triacetyloleandomycinum
    • Tribiocillina
    see all
  • Biological description

    Macrolide antibiotic. Cytochrome P450 3A4 inhibitor. Inhibits NO release from Glycerol trinitrate (GTN). Anti-asthmatic activity in vivo.

  • Purity

    > 98%
  • CAS Number

    2751-09-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Cheng CY  et al. Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4. J Steroid Biochem Mol Biol 159:131-41 (2016). Read more (PubMed: 26970587) »
  • McGinnity DF  et al. Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells. Drug Metab Dispos 37:1259-68 (2009). Read more (PubMed: 19307295) »
  • Kozlov AV  et al. Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver. Br J Pharmacol 139:989-97 (2003). Read more (PubMed: 12839873) »
  • Yamazaki H & Shimada T Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Drug Metab Dispos 26:1053-7 (1998). Read more (PubMed: 9806945) »
  • Delaforge M  et al. In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: comparison with troleandomycin and erythromycin. Chem Biol Interact 68:179-88 (1988). Read more (PubMed: 3265076) »
  • Weinberger M  et al. Inhibition of theophylline clearance by troleandomycin. J Allergy Clin Immunol 59:228-31 (1977). Read more (PubMed: 300083) »
  • Ludden TM Pharmacokinetic interactions of the macrolide antibiotics. Clin Pharmacokinet 10:63-79 (0). Read more (PubMed: 3882305) »

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