Overview

  • Product name

    Tropicamide, M4 antagonist
  • Description

    Potent, selective M4 antagonist
  • Biological description

    Potent, selective M4 antagonist (pKi = 7.85).
  • Purity

    > 98%
  • CAS Number

    1508-75-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Ethyl-α-(hydroxymethyl)-N-(4-pyridylmethyl)benzeneacetamide
  • Molecular weight

    284.36
  • Molecular formula

    C17H20N2O2
  • PubChem identifier

    5593
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    OCC(c1ccccc1)C(=O)N(CC)Cc2ccncc2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nakamura M & Jang IS Muscarinic M(4) receptors regulate GABAergic transmission in rat tuberomammillary nucleus neurons. Neuropharmacology : (2012). Read more (PubMed: 22828639) »
  • Betz AJ  et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl) 194:347-59 (2007). Read more (PubMed: 17594079) »
  • De Amici M  et al. Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands. Farmaco 58:739-48 (2003). Read more (PubMed: 13679167) »

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