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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Troponin
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Anti-Troponin I fast skeletal muscle antibody (ab134838)

  • Datasheet
  • SDS
Submit a review Submit a question References (3)

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Western blot - Anti-Troponin I fast skeletal muscle antibody (ab134838)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin I fast skeletal muscle antibody (ab134838)

Key features and details

  • Rabbit polyclonal to Troponin I fast skeletal muscle
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human Troponin I fast skeletal muscle protein (denatured) (ab137152)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Troponin I fast skeletal muscle antibody
    See all Troponin I fast skeletal muscle primary antibodies
  • Description

    Rabbit polyclonal to Troponin I fast skeletal muscle
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Troponin I fast skeletal muscle.

  • Positive control

    • Human Skeletal Muscle tissue; Human brain lysates
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microfilaments
    • Actin etc
    • Troponin

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Troponin I fast skeletal muscle protein (denatured) (ab137152)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab134838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/200 - 1/500. Predicted molecular weight: 21 kDa.
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
WB
1/200 - 1/500. Predicted molecular weight: 21 kDa.
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • Involvement in disease

    Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B) [MIM:601680]; also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin.
  • Sequence similarities

    Belongs to the troponin I family.
  • Target information above from: UniProt accession P48788 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 7136 Human
    • Entrez Gene: 21953 Mouse
    • Entrez Gene: 29389 Rat
    • Omim: 191043 Human
    • SwissProt: P48788 Human
    • SwissProt: P13412 Mouse
    • SwissProt: P27768 Rat
    • Unigene: 523403 Human
    • Unigene: 39469 Mouse
    • Unigene: 9924 Rat
    see all
  • Alternative names

    • AMCD 2B antibody
    • AMCD2B antibody
    • DA 2B antibody
    • DA2B antibody
    • fast skeletal muscle antibody
    • Fast twitch skeletal muscle troponin I antibody
    • fast-twitch isoform antibody
    • FSSV antibody
    • fsTnI antibody
    • TNNI 2 antibody
    • Tnni2 antibody
    • TNNI2_HUMAN antibody
    • tro antibody
    • Troponin I antibody
    • Troponin I fast skeletal muscle antibody
    • Troponin I fast twitch 2 antibody
    • Troponin I fast twitch isoform antibody
    • Troponin I fast twitch skeletal muscle isoform antibody
    • Troponin I skeletal fast antibody
    • Troponin I type 2 (skeletal fast) antibody
    • Troponin I type 2 antibody
    see all

Images

  • Western blot - Anti-Troponin I fast skeletal muscle antibody (ab134838)
    Western blot - Anti-Troponin I fast skeletal muscle antibody (ab134838)
    Anti-Troponin I fast skeletal muscle antibody (ab134838) at 1/200 dilution + Human Brain lysate

    Predicted band size: 21 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin I fast skeletal muscle antibody (ab134838)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin I fast skeletal muscle antibody (ab134838)
    Immunohistochemistry analysis of formalin fixed, paraffin embedded Human Skeletal Muscle tissue labelling Troponin I fast skeletal muscle with ab134838 at 5 µg/ml.

Protocols

  • Western blot protocols
  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (3)

Publishing research using ab134838? Please let us know so that we can cite the reference in this datasheet.

ab134838 has been referenced in 3 publications.

  • Morisasa M  et al. Investigation of the Lipid Changes That Occur in Hypertrophic Muscle due to Fish Protein-feeding Using Mass Spectrometry Imaging. J Oleo Sci 68:141-148 (2019). PubMed: 30713267
  • De Matteis A  et al. The Troponin-I fast skeletal muscle is reliable marker for the determination of vitality in the suicide hanging. Forensic Sci Int 301:284-288 (2019). PubMed: 31195249
  • Ponnusamy S  et al. Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy. Hum Mol Genet 26:2526-2540 (2017). PubMed: 28453658

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