Trospium chloride, Competitive M2 and M3 mAChR antagonist (ab143218)

Overview

  • Product name

    Trospium chloride, Competitive M2 and M3 mAChR antagonist
  • Description

    Competitive M2 and M3 mAChR antagonist
  • Biological description

    Competitive M2 and M3 mAChR antagonist. Shows antispasmodic and renoprotective effects in vivo. Weakly blood-brain barrier permeable. Orally active.
  • Purity

    > 99%
  • CAS Number

    10405-02-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate chloride
  • Molecular weight

    427.96
  • Molecular formula

    C25H30ClNO3
  • PubChem identifier

    107979
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kranz J  et al. Brain penetration of the OAB drug trospium chloride is not increased in aged mice. World J Urol 31:219-24 (2013). Read more (PubMed: 22120415) »
  • Karaman A  et al. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction. Urology 82:194-200 (2013). Read more (PubMed: 23453648) »
  • Beckmann-Knopp S  et al. Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes. Pharmacol Toxicol 85:299-304 (1999). Read more (PubMed: 10628907) »

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