Overview

  • Product name

    Anti-TRP1 antibody [TA99] - BSA and Azide free
    See all TRP1 primary antibodies
  • Description

    Mouse monoclonal [TA99] to TRP1 - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cyt, IHC-Fr, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Tissue, cells or virus corresponding to Human TRP1. (SK-MEL-23 cells).

  • Positive control

    • SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells; Melanoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab212922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.5-1µg for 106 cells.

(in 0.1 ml).

IHC-Fr Use a concentration of 0.5 - 1 µg/ml.

(For 30 minutes at RT).

IHC-P Use a concentration of 3 - 6 µg/ml.
ICC/IF Use a concentration of 1 - 2 µg/ml.

Target

  • Function

    Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
  • Tissue specificity

    Pigment cells.
  • Pathway

    Pigment biosynthesis; melanin biosynthesis.
  • Involvement in disease

    Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
  • Sequence similarities

    Belongs to the tyrosinase family.
  • Cellular localization

    Melanosome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5 antibody
    • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
    • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
    • b-PROTEIN antibody
    • CAS2 antibody
    • Catalase B antibody
    • CATB antibody
    • DHICA oxidase antibody
    • Glycoprotein 75 antibody
    • GP75 antibody
    • Melanoma antigen gp75 antibody
    • OCA3 antibody
    • TRP antibody
    • TRP-1 antibody
    • TRP1 antibody
    • Tyrosinase related protein 1 antibody
    • Tyrosinase-related protein 1 antibody
    • TYRP antibody
    • TYRP1 antibody
    • TYRP1_HUMAN antibody
    • TYRRP antibody
    see all

Images

  • Immunohistochemical analysis of Formalin fixed, paraffin-embedded human Melanoma sections labelling TRP1 with ab212922 at 3–6 ug/mL. Antigen retrieval was boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes.

References

ab212922 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab212922.
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