Product nameTRPA1 peptide
Our Abpromise guarantee covers the use of ab204483 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This is the blocking peptide for ab62053.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
- ANKTM 1
- Ankyrin-like with transmembrane domains protein 1
FunctionReceptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Tissue specificityExpressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family.
Contains 15 ANK repeats.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab204483 has not yet been referenced specifically in any publications.