Overview

Description

  • Nature

    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab62053.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • ANKTM 1
    • ANKTM1
    • Ankyrin-like with transmembrane domains protein 1
    • Transformation sensitive protein p120
    • Transformation-sensitive protein p120
    • Transient receptor potential cation channel subfamily A member 1
    • TRPA 1
    • Trpa1
    • TRPA1_HUMAN
    see all
  • Function

    Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
  • Tissue specificity

    Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
  • Sequence similarities

    Belongs to the transient receptor (TC 1.A.4) family.
    Contains 15 ANK repeats.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab204483 has not yet been referenced specifically in any publications.

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