Product nameAnti-TRPA1/TSA antibody
See all TRPA1/TSA primary antibodies
DescriptionRabbit polyclonal to TRPA1/TSA
Tested applicationsSuitable for: IP, IHC-Fr, IHC-FoFr, IHC-P, IHC - Wholemountmore details
Species reactivityReacts with: Rat
Predicted to work with: Human
General notesWe have mixed feedback about mouse specificity from our customers which is why we no longer support this species.
This product was previously labelled as TRPA1
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservative: 0.05% Sodium azide
Our Abpromise guarantee covers the use of ab58844 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration. PubMed: 25023795|
|IHC-Fr||Use at an assay dependent concentration.|
|IHC-FoFr||Use at an assay dependent concentration. PubMed: 21750223|
|IHC-P||Use at an assay dependent concentration. PubMed: 24358160|
|IHC - Wholemount||Use at an assay dependent concentration. PubMed: 19632231|
FunctionReceptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Tissue specificityExpressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family.
Contains 15 ANK repeats.
- Information by UniProt
- ANKTM 1 antibody
- ANKTM1 antibody
- Ankyrin-like with transmembrane domains protein 1 antibody
Immunohistochemical analysis of murine distal colon tissue, staining TRPA1/TSA with ab58844.
Sections were incubated with primary antibody (1/1000) overnight at 4°C. An AlexaFluor®488-conjugated anti-rabbit IgG was used as the secondary antibody. ab36001 was used to stain CGRP (red).
Immunohistochemical analysis of wholemount murine colonic wall, staining TRPA1/TSA with ab58844.
Wholemount preparations were incubated with primary antibody (1/1000) overnight at 37°C. An AlexaFluor®488-conjugated anti-rabbit IgG was used as the secondary antibody.
This product has been referenced in:
- Xia M et al. TRPA1 Activation-Induced Myelin Degradation Plays a Key Role in Motor Dysfunction After Intracerebral Hemorrhage. Front Mol Neurosci 12:98 (2019). Read more (PubMed: 31057367) »
- Chen X et al. Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure. J Neurogastroenterol Motil 25:442-460 (2019). Read more (PubMed: 31327223) »