Anti-TRPC3 antibody (ab51560)
Key features and details
- Rabbit polyclonal to TRPC3
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-TRPC3 antibody
See all TRPC3 primary antibodies -
Description
Rabbit polyclonal to TRPC3 -
Host species
Rabbit -
Specificity
ab51560 can be used for the detection of TRPC3. -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human TRPC3 (N terminal). Corresponding to 14 amino acids near to the N terminal of Human TRPC3.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab51560 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use at an assay dependent concentration.
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IHC-P | (1) |
Use a concentration of 10 µg/ml.
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Notes |
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WB
Use at an assay dependent concentration. |
IHC-P
Use a concentration of 10 µg/ml. |
Target
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Relevance
TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble. -
Cellular localization
Cell Membrane; multi-pass membrane protein -
Database links
- Entrez Gene: 7222 Human
- Entrez Gene: 22065 Mouse
- Omim: 602345 Human
- SwissProt: Q13507 Human
- SwissProt: Q9QZC1 Mouse
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Alternative names
- Htrp 3 antibody
- Htrp3 antibody
- MGC124333 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (16)
ab51560 has been referenced in 16 publications.
- Chen PH et al. Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca2+ Entry. Int J Mol Sci 22:N/A (2021). PubMed: 33467715
- Lee TW et al. Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling. Int J Mol Sci 23:N/A (2021). PubMed: 35008591
- Rafael Lopez J et al. Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia. Anesthesiology 133:364-376 (2020). PubMed: 32665491
- Fletcher NF et al. A novel antiviral formulation inhibits a range of enveloped viruses. J Gen Virol 101:1090-1102 (2020). PubMed: 32692647
- Deurloo MHS et al. Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models. Mol Neurobiol 56:3313-3325 (2019). PubMed: 30120731