Overview

  • Product name

    Anti-TRPC3 antibody - C-terminal
    See all TRPC3 primary antibodies
  • Description

    Rabbit polyclonal to TRPC3 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human TRPC3 (C terminal). 14 amino acids. NP_003296.1.
    Database link: Q13507-3

  • Positive control

    • Human brain tissue lysate, Human skeletal muscle tissue and mouse heart cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab188802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 97 kDa.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Relevance

    TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.
  • Cellular localization

    Cell Membrane; multi-pass membrane protein
  • Database links

  • Alternative names

    • Htrp 3 antibody
    • Htrp3 antibody
    • MGC124333 antibody
    • Mtrp3 antibody
    • Receptor activated cation channel TRP3 antibody
    • Short transient receptor potential channel 3 antibody
    • Transient receptor potential cation channel subfamily C member 3 antibody
    • transient receptor potential cation channel subfamily C member 3 variant c antibody
    • Transient receptor potential channel 3 antibody
    • TRANSIENT RECEPTOR POTENTIAL DROSOPHILA HOMOLOG OF 3 antibody
    • Transient receptor protein 3 antibody
    • Trp related protein 3 antibody
    • TRP3 antibody
    • TrpC3 antibody
    • Trrp3 antibody
    see all

Images

  • Immunofluorescent analysis of mouse heart cells, labeling TRPC3 with ab188802 at 20 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skeletal muscle tissue labeling TRPC3 with ab188802 at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

  • Lane 1 : Anti-TRPC3 antibody - C-terminal (ab188802) at 1 µg/ml
    Lane 2 : Anti-TRPC3 antibody - C-terminal (ab188802) at 2 µg/ml

    All lanes : Human brain tissue lysate

    Predicted band size: 97 kDa

References

This product has been referenced in:

  • Chen Y  et al. HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells. J Neurovirol N/A:N/A (2018). Read more (PubMed: 30397826) »
  • Aravamudan B  et al. Mechanisms of BDNF regulation in asthmatic airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 311:L270-9 (2016). Read more (PubMed: 27317689) »
See all 2 Publications for this product

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