Key features and details
- Rabbit polyclonal to TRPC6 - C-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TRPC6 antibody - C-terminal
See all TRPC6 primary antibodies
DescriptionRabbit polyclonal to TRPC6 - C-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- 293T, A431, H1299, HeLaS3,A549 whole cell, HepG2 and Raji whole cell lysates
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 59.99% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab137475 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 106 kDa.|
FunctionThought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Tissue specificityExpressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Involvement in diseaseDefects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
Contains 4 ANK repeats.
- Information by UniProt
- bZ1P14.9 antibody
- FLJ11098 antibody
- FLJ14863 antibody
Anti-TRPC6 antibody - C-terminal (ab137475) at 1/3000 dilution + HeLa S3 whole cell lysate at 30 µg
Predicted band size: 106 kDa
7.5% SDS PAGE
All lanes : Anti-TRPC6 antibody - C-terminal (ab137475) at 1/3000 dilution
Lane 1 : A549 whole cell
Lane 2 : A549 membrane extract
Lysates/proteins at 30 µg per lane.
Predicted band size: 106 kDa
ab137475 has not yet been referenced specifically in any publications.