Key features and details
- Goat polyclonal to TRPM2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TRPM2 antibody
See all TRPM2 primary antibodies
DescriptionGoat polyclonal to TRPM2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Cow
Synthetic peptide, conjugated to KLH, corresponding to a region within the internal sequence of Human TRPM2.
- Human brain cortex and pancreas tissues.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab110895 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionNonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Tissue specificityHighly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Contains 1 nudix hydrolase domain.
- Information by UniProt
- EREG 1 antibody
- EREG1 antibody
- Estrogen responsive element associated gene 1 antibody
ab110895, at 3.75 µg/ml, staining TRPM2 in formalin fixed, paraffin embedded Human brain cortex tissue by Immunohistochemistry. A biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen was used to develop staining.
ab110895, at 3.75 µg/ml, staining TRPM2 in formalin fixed, paraffin embedded Human pancreas tissue by Immunohistochemistry. A biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen was used to develop staining.
ab110895 has not yet been referenced specifically in any publications.