Key features and details
- Rabbit polyclonal to TRPM3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-TRPM3 antibody
DescriptionRabbit polyclonal to TRPM3
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab56171 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1.25 µg/ml. Predicted molecular weight: 198 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
RelevanceTransient receptor potential cation channel, subfamily M, member 3 (TRPM3) belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation selective channels important for cellular calcium signaling and homeostasis. TRPM3 mediates calcium entry, and this entry is potentiated by calcium store depletion. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. The TRPM3-mediated calcium entry is inhibited by the nonselective calcium channel blocker lanthanide gadolinium. Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Alternatively spliced transcript variants encoding different isoforms have been identified.
Cellular localizationMembrane; multi pass membrane protein.
- GON2 antibody
- long transient receptor potential channel 3 antibody
- LTrpC 3 antibody
ab56171 has been referenced in 2 publications.
- Yajima T et al. Transient receptor potential melastatin-3 in the rat sensory ganglia of the trigeminal, glossopharyngeal and vagus nerves. J Chem Neuroanat 96:116-125 (2019). PubMed: 30639448
- Lin X et al. Arterial Calcification Is Regulated Via an miR-204/DNMT3a Regulatory Circuit Both In Vitro and in Female Mice. Endocrinology 159:2905-2916 (2018). PubMed: 29850805