• Product name
  • Description
    Goat polyclonal to TRPM7
  • Host species
  • Tested applications
    Suitable for: IHC-P, IHC-Fr, ELISA, ICC/IF, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Crayfish
    Predicted to work with: Dog, Pig
  • Immunogen

    Synthetic peptide: TKESESTNSVRLML, corresponding to C terminal amino acids 1852-1865 of Human TRPM7.

  • Positive control
    • Daudi lysate
  • General notes

    In response to customer feedback and in-house testing the latest lot doesn't pass the WB quality testing so we have decided to remove the application for now. Please contact technical@abcam.com for more details.


    Please see reference He et al for details of the size of the protein detected by SDS-PAGE. Principal Names: TRPM7; transient receptor potential cation channel, subfamily M, member 7; CHAK; CHAK1; LTRPC7; FLJ20117; TRP-PLIK; LTRPC ion channel family member 7; homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK hypothetical protein. Official Gene Symbol - TRPM7 GenBank Accession Number – XP_030709 LocusLink ID - 54822 (human).

     Can be blocked with Human TRPM7 peptide (ab22777).




Our Abpromise guarantee covers the use of ab729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration. PubMed: 21183474
IHC-Fr 1/1000. PubMed: 16285951
ELISA 1/16000.
ICC/IF Use at an assay dependent concentration. PubMed: 16285951
IHC-FoFr Use at an assay dependent concentration. PubMed: 19734892


  • Function
    Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
  • Involvement in disease
    Defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 (ALS-PDC1) [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
  • Sequence similarities
    In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
    In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
    Contains 1 alpha-type protein kinase domain.
  • Post-translational
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • ALSPDC antibody
    • CHAK antibody
    • CHAK1 antibody
    • Channel kinase 1 antibody
    • Channel-kinase 1 antibody
    • Long transient receptor potential channel 7 antibody
    • LTrpC-7 antibody
    • LTrpC7 antibody
    • Transient receptor potential cation channel subfamily M member 7 antibody
    • TRP PLIK antibody
    • TRPM7 antibody
    • TRPM7_HUMAN antibody
    see all


This product has been referenced in:
  • Liu A  et al. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury. Sci Rep 8:5510 (2018). Read more (PubMed: 29615639) »
  • Gao SL  et al. TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth. Oncol Rep 38:1967-1976 (2017). Read more (PubMed: 28791418) »

See all 16 Publications for this product

Customer reviews and Q&As

Could you send us the following information;

- lot number
- purchase order number


Thank you for your email. I am sorry to hear that you have been experiencing problems with this antibody.

I have read the details you have kindly provided and would like to investigate the complaint further. Could you send us the publication o...

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Thank you for your reply.

For anti-TRPM7 the immunogen region for ab729 and ab72155 show 100% homology with the bovine sequence. Therefore, either of these antibodies should work with bovine.


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Thank you for contacting us.

The ab let me know the following:
The observed molecular weight corresponds to earlier findings in the literature with different antibodies. We are not sure if this applies also to TRPM6.

I hope t...

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Thank you for contacting us.

I am checking with the lab regarding ab729 and will let you know.

As for TRPM6, which antibody are you refering to?

I look forward to hear back from you.

Use our products? Submit a...

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Thank you for your reply. The details provided enable us to closely monitor the quality of our products.

I am sorry these products did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have iss...

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Thank you for your email.

I can definitely send you 2 replacement antibodies to the address you mentioned, but I would need to know which ones you'd like to receive.

I can send the same antibodies and different lots if we have them...

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Thank you for your reply.

I have located both your orders for ab729 and ab85016.

Could you please let me know if you would prefer a free of charge replacement for each of the antibodies, a credit or refund? We do carry other TRPM7 ...

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Thank you for your recent participation in our survey.
I am very sorry to hear that the protocol tips did not work.

You had used ab729 as well as ab85016.What tips have you tried and have the results changed at all?

Please let ...

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Thank you for contacting us. I have received WB protocol information for ab729, but am still waiting for more information regarding ab85016. Thank you for your continued patience in the meantime. For ab729, we have seen a 150-160kDa band in DDI, ...

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