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    trpv3-antibody-ab231150.pdf

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Neuroscience Neurotransmission Receptors / Channels Ligand-Gated Ion Channels More Channels
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Anti-TRPV3 antibody (ab231150)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)
  • Western blot - Anti-TRPV3 antibody (ab231150)
  • Western blot - Anti-TRPV3 antibody (ab231150)

Key features and details

  • Rabbit polyclonal to TRPV3
  • Suitable for: IHC-P, WB
  • Reacts with: Rat, Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-TRPV3 antibody
    See all TRPV3 primary antibodies
  • Description

    Rabbit polyclonal to TRPV3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment (His-T7-tag) corresponding to Human TRPV3 aa 671-790. Expressed in E. coli.
    Sequence:

    NMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRN NSKTTLNAFEEVEEFPETSV


    Database link: Q8NET8-1
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • WB: Recombinant human TRPV3 protein; Rat cerebrum lysate. IHC-P: Human breast cancer tissue; Kidney tissue.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • More Channels
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • More Ion Channels
    • Neuroscience
    • Sensory System
    • Somatosensory system
    • Nociception

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

Our Abpromise guarantee covers the use of ab231150 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 20 µg/ml.
WB Use a concentration of 0.2 - 2 µg/ml. Predicted molecular weight: 91 kDa.

Target

  • Function

    Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.
  • Tissue specificity

    Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).
  • Sequence similarities

    Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.
    Contains 3 ANK repeats.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession Q8NET8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 162514 Human
    • Entrez Gene: 497948 Rat
    • Omim: 607066 Human
    • SwissProt: Q8NET8 Human
    • Unigene: 446255 Human
    • Unigene: 163151 Rat
    • Alternative names

      • 1110036I10Rik antibody
      • MGC124324 antibody
      • MGC124325 antibody
      • Transient receptor potential cation channel subfamily V member 3 antibody
      • TrpV3 antibody
      • Trpv3 heat sensitive channel antibody
      • TRPV3_HUMAN antibody
      • Vanilloid receptor 3 antibody
      • Vanilloid receptor like 3 antibody
      • Vanilloid receptor-like 3 antibody
      • vanilloid receptor-related osmotically activated channel protein antibody
      • VRL 3 antibody
      • VRL-3 antibody
      • VRL3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)

      Formalin-fixed, paraffin-embedded human breast cancer tissue stained for TRPV3 with ab231150 at 20 µg/ml in immunohistochemical analysis. DAB staining.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (ab231150)

      Formalin-fixed, paraffin-embedded human kidney tissue stained for TRPV3 with ab231150 at 20 µg/ml in immunohistochemical analysis. DAB staining.

    • Western blot - Anti-TRPV3 antibody (ab231150)
      Western blot - Anti-TRPV3 antibody (ab231150)
      Anti-TRPV3 antibody (ab231150) at 2 µg/ml + Rat cerebrum lysate

      Predicted band size: 91 kDa

    • Western blot - Anti-TRPV3 antibody (ab231150)
      Western blot - Anti-TRPV3 antibody (ab231150)
      Anti-TRPV3 antibody (ab231150) at 2 µg/ml + Recombinant human TRPV3 protein

      Predicted band size: 91 kDa

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab231150? Please let us know so that we can cite the reference in this datasheet.

    ab231150 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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