Overview

  • Product name

  • Description

    Rabbit polyclonal to TRPV4
  • Host species

    Rabbit
  • Specificity

    ab191580 is predicted to not cross-react with other TRP protein family members.
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Horse
  • Immunogen

    Synthetic peptide corresponding to Human TRPV4 (internal sequence). (18 amino acids). NP_067638.3.
    Database link: Q9HBA0

  • Positive control

    • Human testis tissue lysate; Human lung tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab191580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 98 kDa).
IHC-P Use a concentration of 2 µg/ml.
ICC/IF Use a concentration of 5 µg/ml.

Target

  • Function

    Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
  • Tissue specificity

    Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
  • Involvement in disease

    Brachyolmia 3
    Spondylometaphyseal dysplasia Kozlowski type
    Metatropic dysplasia
    Distal spinal muscular atrophy, congenital non-progressive
    Charcot-Marie-Tooth disease 2C
    Scapuloperoneal spinal muscular atrophy
    Spondyloepiphyseal dysplasia Maroteaux type
    Parastremmatic dwarfism
    Digital arthropathy-brachydactyly, familial
  • Sequence similarities

    Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
    Contains 3 ANK repeats.
  • Post-translational
    modifications

    Phosphorylation results in enhancement of its channel function.
  • Cellular localization

    Cell membrane and Cell membrane. Cell junction > adherens junction. Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • BCYM3 antibody
    • CMT2C antibody
    • HMSN2C antibody
    • osm 9 like TRP channel 4 antibody
    • Osm-9-like TRP channel 4 antibody
    • OSM9 like transient receptor potential channel 4 antibody
    • Osmosensitive transient receptor potential channel 4 antibody
    • OTRPC 4 antibody
    • OTRPC4 antibody
    • SMAL antibody
    • SPSMA antibody
    • SSQTL1 antibody
    • Transient receptor potential cation channel subfamily V member 4 antibody
    • Transient receptor potential protein 12 antibody
    • TRP 12 antibody
    • TRP12 antibody
    • TRPV 4 antibody
    • TrpV4 antibody
    • TRPV4_HUMAN antibody
    • Vanilloid receptor like channel 2 antibody
    • Vanilloid receptor like protein 2 antibody
    • Vanilloid receptor related osmotically activated channel antibody
    • Vanilloid receptor-like channel 2 antibody
    • Vanilloid receptor-like protein 2 antibody
    • Vanilloid receptor-related osmotically-activated channel antibody
    • VR 4 antibody
    • VR OAC antibody
    • VR-OAC antibody
    • VR4 antibody
    • VRL 2 antibody
    • VRL-2 antibody
    • VRL2 antibody
    • VROAC antibody
    see all

Images

  • Western Blot of human testis tissue lysate, SK-N-SH cell lysate labeling TRPV4 with Anti-TRPV4 antibody (ab191580) at 1µg/ml.
  • Immunofluorescent analysis of TRPV4 expression in human kidney tissue with ab191580 at 5µg/ml.
  • Anti-TRPV4 antibody (ab191580) at 1 µg/ml + Human testis tissue lysate at 15 µg

    Predicted band size: 98 kDa

  • Immunohistochemical analysis of paraffin-embedded human lung tissue labeling TRPV4 with ab191580 at 5 µg/ml.

  • Immunofluorescent analysis of human lung tissue labeling TRPV4 with ab191580 at 20 µg/ml.

References

ab191580 has not yet been referenced specifically in any publications.

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