TRx0237 mesylate (LMTX), Tau protein aggregation inhibitor (ab223882)

Overview

  • Product name

    TRx0237 mesylate (LMTX), Tau protein aggregation inhibitor
  • Description

    Tau protein aggregation inhibitor
  • Alternative names

    • Leucomethylene blue mesylate
    • LMTX mesylate
  • Biological description

    TRx0237 mesylate is a second-generation tau protein aggregation inhibitor for treatment of Alzheimer's disease (AD) and frontotemporal dementia. Has neuroprotective activity in vitro and in vivo. 


     

  • Purity

    > 99%
  • CAS Number

    1236208-20-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dimesylate

  • Molecular weight

    447.62
  • Molecular formula

    C16H19N3S.2CH3SO3H
  • PubChem identifier

    60150609
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 100 mM and in water to 100 mM

  • SMILES

    CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Panza F  et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother 17:457-61 (2016). Read more (PubMed: 26809554) »
  • Doig AJ & Derreumaux P Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol 30:50-6 (2015). Read more (PubMed: 25559306) »
  • Harrington CR  et al. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. J Biol Chem 290:10862-75 (2015). Read more (PubMed: 25759392) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab223882.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up