Tryprostatin A, MAP-dependent microtubule assembly inhibitor (ab143558)

Overview

  • Product name

    Tryprostatin A, MAP-dependent microtubule assembly inhibitor
  • Description

    Selective MAP-dependent microtubule assembly inhibitor
  • Biological description

    Selective MAP-dependent microtubule assembly inhibitor. Disrupts mitotic spindle. Induces cell cycle arrest at G2/M phase. Inhibits BCRP. Shows antimitotic effects.
  • Purity

    > 92%
  • CAS Number

    171864-80-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,8aS)-3-[[6-methoxy-2-(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Molecular weight

    381.47
  • Molecular formula

    C22H27N3O3
  • PubChem identifier

    9929833
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCC1=C(C2=C(N1)C=C(C=C2)OC)CC3C(=O)N4CCCC4C(=O)N3)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Fani N  et al. Computational design of Tryprostatin-A derivatives as novel aß-tubulin inhibitors. J Biomol Struct Dyn : (2014). Read more (PubMed: 24606044) »
  • Jain HD  et al. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem 16:4626-51 (2008). Read more (PubMed: 18321710) »
  • Usui T  et al. Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem J 333 ( Pt 3):543-8 (1998). Read more (PubMed: 9677311) »

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