Overview

  • Product name
    Anti-Trypsin antibody [7C8]
    See all Trypsin primary antibodies
  • Description
    Mouse monoclonal [7C8] to Trypsin
  • Host species
    Mouse
  • Specificity
    This antibody is specific for human trypsin, trypsinogen and trypsin in complex with alpha 1 antitrypsin.
  • Tested applications
    Suitable for: Sandwich ELISA, WB, ELISAmore details
  • Species reactivity
    Reacts with: Cow, Human
  • Immunogen

    Full length native protein purified from human pancreatic tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab17262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent dilution. Can be used as a capture antibody in conjugation with recommended pair.
WB Use at an assay dependent dilution. Detects a band of approximately 24 kDa.
ELISA 1/1500. Can be paired for ELISA with Mouse monoclonal [021-03] to Trypsin (Biotin) (ab64113).

Target

  • Function
    Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
  • Involvement in disease
    Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
  • Cellular localization
    Secreted > extracellular space.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha-trypsin chain 2 antibody
    • Anionic trypsinogen antibody
    • Beta trypsin antibody
    • Beta-trypsin antibody
    • Brain trypsinogen antibody
    • Cationic trypsinogen antibody
    • Digestive zymogen antibody
    • Mesotrypsin antibody
    • Mesotrypsinogen antibody
    • MGC111183 antibody
    • MGC120174 antibody
    • MGC120175 antibody
    • MGC149362 antibody
    • MTG antibody
    • Nonfunctional trypsin 1 antibody
    • Pancreatic trypsinogen III antibody
    • Protease serine 1 (trypsin 1) antibody
    • Protease Serine 1 antibody
    • Protease serine 2 (trypsin 2) antibody
    • Protease serine 2 antibody
    • Protease serine 2 preproprotein antibody
    • Protease serine 3 (mesotrypsin) antibody
    • Protease serine 3 antibody
    • Protease serine 4 (trypsin 4 brain) antibody
    • Prss1 antibody
    • PRSS2 antibody
    • PRSS3 antibody
    • PRSS4 antibody
    • Serine protease 1 antibody
    • Serine protease 2 antibody
    • Serine protease 3 antibody
    • Serine protease 4 antibody
    • T9 antibody
    • TCR V beta 4.1 antibody
    • TRP1 antibody
    • TRY1 antibody
    • TRY1_HUMAN antibody
    • TRY2 antibody
    • TRY3 antibody
    • TRY4 antibody
    • TRY8 antibody
    • TRYP1 antibody
    • TRYP2 antibody
    • Trypsin 1 antibody
    • Trypsin 2 antibody
    • Trypsin 3 antibody
    • Trypsin I antibody
    • Trypsin II antibody
    • Trypsin III antibody
    • Trypsin IV antibody
    • Trypsinogen 1 antibody
    • Trypsinogen 2 antibody
    • Trypsinogen 4 antibody
    • Trypsinogen 5 antibody
    • Trypsinogen A antibody
    • Trypsinogen IV antibody
    • Trypsinogen, anionic antibody
    • Trypsinogen, cationic antibody
    see all

References

This product has been referenced in:
  • Baginski L  et al. Investigations into the fate of inhaled salmon calcitonin at the respiratory epithelial barrier. Pharm Res 29:332-41 (2012). WB ; Human . Read more (PubMed: 21818710) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your enquiry. Some of our antibodies are produced in-house and others are sourced from suppliers or academic collaborators whose products we believe will be of interest to our customers. All these products are guaranteed by our Abpromise to be of high quality. Our Abpromise assures you that if our products do not perform as our datasheets say they should we offer a replacement or refund within 120 days of purchase. Some of our collaborators are not certified ISO9001 and so we are not able to provide a certificate of analysis for these particular products. As the identity of our collaborators is confidential, we provide a certificate of compliance for all of our products available in our catalogue. This document certifies that our products meet the required specifications for a particular lot/batch of product. I have attached a Certificate of Compliance to this e-mail for you. Please do not hesitate to contact me again if you have further questions.  

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Answer

Thank you for contacting Abcam. Attached please find the Certificate of Compliance document you requested. I hope this information is helpful. Please do not hesitate to contact us if you have any additional questions.

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