Overview

  • Product name

    Anti-TSPAN12 antibody
  • Description

    Rabbit polyclonal to TSPAN12
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human TSPAN12 aa 34-50 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    WMRDYLN NVLTLTAETR


    Database link: O95859

  • Positive control

    • Rat brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab213678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
  • Cellular localization

    Cell membrane; Multi-pass membrane protein.
  • Database links

  • Alternative names

    • 9030619E17 antibody
    • AI426782 antibody
    • AI663988 antibody
    • AW111457 antibody
    • MGC109305 antibody
    • NET 2 antibody
    • NET2 antibody
    • OTTHUMP00000211224 antibody
    • Tetraspan NET 2 antibody
    • Tetraspanin 12 antibody
    • Tetraspanin12 antibody
    • TM4SF12 antibody
    • Transmembrane 4 superfamily member 12 antibody
    • TSPAN 12 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling TSPAN12 with ab213678 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab213678 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab213678.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up