Overview

  • Product name

    Anti-TSPY1/TSPY antibody - C-terminal
    See all TSPY1/TSPY primary antibodies
  • Description

    Rabbit polyclonal to TSPY1/TSPY - C-terminal
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of TSPY1/TSPY are known to exist; ab189383 will detect only TSPY1S.

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human TSPY1/TSPY (C terminal). 13 amino acids long, near the C-terminus. NP_003299.2.
    Database link: Q01534

  • Positive control

    • Human testis tissue; A20 cell lysate.
  • General notes

     This product was previously labelled as TSPY1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab189383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 35 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    May be involved in sperm differentiation and proliferation.
  • Tissue specificity

    Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines.
  • Involvement in disease

    Note=TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland.
  • Sequence similarities

    Belongs to the nucleosome assembly protein (NAP) family.
  • Developmental stage

    Detected in 22-week old testis.
  • Post-translational
    modifications

    Phosphorylated.
  • Cellular localization

    Cytoplasm. Nucleus. Predominantly cytoplasmic. Also found in nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cancer/testis antigen 78 antibody
    • CT78 antibody
    • DYS14 antibody
    • pJA 923 antibody
    • pJA923 antibody
    • Testis specific protein Y linked 1 antibody
    • Testis specific Y encoded protein 1 antibody
    • Testis-specific Y-encoded protein 1 antibody
    • TSPY 1 antibody
    • TSPY antibody
    • Tspy1 antibody
    • TSPY1_HUMAN antibody
    see all

Images

  • All lanes : Anti-TSPY1/TSPY antibody - C-terminal (ab189383) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate plus blocking peptide

    Predicted band size: 35 kDa

  • Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded Human testis tissue sections labeling TSPY1/TSPY using ab189383 at 5 µg/ml.

References

This product has been referenced in:

  • Li S  et al. Over-expressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma. PLoS One 9:e89219 (2014). Human . Read more (PubMed: 24586606) »
See 1 Publication for this product

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