TTA-A2, T-type voltage gated Ca2+ channel blocker (ab145559)
- Datasheet
- References
Overview
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Product name
TTA-A2, T-type voltage gated Ca2+ channel blocker -
Description
Potent and selective T-type voltage gated Ca2+ channel blocker -
Biological description
Potent, selective T-type voltage gated Ca2+ channel blocker (IC50 values are 89 nM and 4.1 μM for CaV3.1 at -80 and -100 mV holding potentials respectively). Shows antipulmonary hypertensive, soporific and other central effects in vivo. Orally active. -
Purity
> 98% -
Chemical structure
Properties
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Chemical name
2-(4-Cyclopropylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide -
Molecular weight
378.39 -
Molecular formula
C20H21F3N2O2 -
PubChem identifier
53317097 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](C1=NC=C(C=C1)OCC(F)(F)F)NC(=O)CC2=CC=C(C=C2)C3CC3 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Gangarossa G et al. T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants. Front Behav Neurosci 8:92 (2014). Read more (PubMed: 24672455) »
- Chevalier M et al. T-type calcium channels are involved in hypoxic pulmonary hypertension. Cardiovasc Res 103:597-606 (2014). Read more (PubMed: 25016616) »
- Kraus RL et al. In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther 335:409-17 (2010). Read more (PubMed: 20682849) »
- Uebele VN et al. Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice. J Clin Invest 119:1659-67 (2009). Read more (PubMed: 19451696) »