TTA-A2, T-type voltage gated Ca2+ channel blocker (ab145559)

Overview

  • Product name

    TTA-A2, T-type voltage gated Ca2+ channel blocker
  • Description

    Potent and selective T-type voltage gated Ca2+ channel blocker
  • Biological description

    Potent, selective T-type voltage gated Ca2+ channel blocker (IC50 values are 89 nM and 4.1 μM for CaV3.1 at -80 and -100 mV holding potentials respectively). Shows antipulmonary hypertensive, soporific and other central effects in vivo. Orally active.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(4-Cyclopropylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide
  • Molecular weight

    378.39
  • Molecular formula

    C20H21F3N2O2
  • PubChem identifier

    53317097
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H](C1=NC=C(C=C1)OCC(F)(F)F)NC(=O)CC2=CC=C(C=C2)C3CC3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gangarossa G  et al. T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants. Front Behav Neurosci 8:92 (2014). Read more (PubMed: 24672455) »
  • Chevalier M  et al. T-type calcium channels are involved in hypoxic pulmonary hypertension. Cardiovasc Res 103:597-606 (2014). Read more (PubMed: 25016616) »
  • Kraus RL  et al. In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther 335:409-17 (2010). Read more (PubMed: 20682849) »
  • Uebele VN  et al. Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice. J Clin Invest 119:1659-67 (2009). Read more (PubMed: 19451696) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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