Overview

  • Product name
    Anti-TTC11 / FIS1 antibody
    See all TTC11 / FIS1 primary antibodies
  • Description
    Rabbit polyclonal to TTC11 / FIS1
  • Host species
    Rabbit
  • Specificity
    ab24242 reacts with Fis1 protein.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide corresponding to Human TTC11/ FIS1 aa 11-25.
    Sequence:

    vedllkfekkfqsek

  • General notes

    Previously labelled as TTC11. 

Properties

Applications

Our Abpromise guarantee covers the use of ab24242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 17 kDa.

Target

  • Function
    Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
  • Sequence similarities
    Belongs to the FIS1 family.
    Contains 1 TPR repeat.
  • Domain
    The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
  • Post-translational
    modifications
    Ubiquitinated by MARCH5.
  • Cellular localization
    Mitochondrion outer membrane. Peroxisome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2010003O14Rik antibody
    • CGI 135 antibody
    • CGI135 antibody
    • FIS 1 antibody
    • FIS1 antibody
    • Fis1 homolog antibody
    • FIS1, S. cerevisiae, homolog of antibody
    • FIS1_HUMAN antibody
    • Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) antibody
    • Fission 1 (mitochondrial outer membrane) homolog (yeast) antibody
    • Fission 1 (mitochondrial outer membrane) homolog antibody
    • Fission 1 homolog antibody
    • H NH0132A01.6 antibody
    • hFis 1 antibody
    • hFis1 antibody
    • Mitochondrial fission 1 protein antibody
    • mitochondrial fission molecule antibody
    • Tetratricopeptide repeat domain 11 antibody
    • Tetratricopeptide repeat protein 11 antibody
    • TPR repeat protein 11 antibody
    • TTC 11 antibody
    • TTC11 antibody
    see all

References

This product has been referenced in:
  • Winden KD  et al. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol 5:291 (2009). WB ; Mouse . Read more (PubMed: 19638972) »
See 1 Publication for this product

Customer reviews and Q&As

Answer

Thank you for contacting us.

The protein sequence of human Fis1 (http://www.uniprot.org/uniprot/Q9Y3D6) and Saccharomyces (http://www.uniprot.org/uniprot/P40515) do not match (http://www.ebi.ac.uk/Tools/services/web_clustalw2/toolresult.ebi?tool=clustalw2&jobId=clustalw2-I20120924-133404-0826-16044361-oy) so I am sorry we cannot predict ab24242could detect the yeast protein.

I hope this information is nevertheless helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our products? Submit an Abreview. Earn rewards!
https://www.abcam.com/abreviews

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up